FORMULATION DEVELOPMENT AND CHARACTERIZATION OF GELUCIRE BEADS OF ANTIHYPERTENSIVE DRUG FOR FLOATING DRUG DELIVERY SYSTEM USING 32 FACTORIAL DESIGNS
نویسندگان
چکیده
Objective: The aim of this study was to design and optimize lipid based beads for multiunit floating drug delivery ramipril.
 Methods: prepared by melt-solidification method. In the investigation 32 full factorial used investigate joint influence two formulation variable amount Gelucire (X1) Tween 20 (X2) as independent percentage release in 1 (Y1), 6 (Y2), 12 h (Y3) dependent variable. 43/01 has chosen retardant solubility enhancement loading agent.
 Results: results multiple linear regression analysis indicated that obtain a delivery, optimum concentrations both agent should be used. models were prepare optimized formulations showed controlled profiles extended period more than h.
 Conclusion: From study, it concluded sparingly water-soluble ramipril can provide period.
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical and Clinical Research
سال: 2021
ISSN: ['0974-2441', '2455-3891']
DOI: https://doi.org/10.22159/ajpcr.2021.v14i3.40532